The MHRA has undertaken a thorough review into UK reports of a very rare and unlikely to occur specific type of blood clot in the brain, known as cerebral venous sinus thrombosis ( CVST) occurring together with low levels of platelets (thrombocytopenia) following vaccination with the COVID-19 Vaccine AstraZeneca. Updated information is being provided for people and healthcare professionals on the possible risk of extremely rare and unlikely to occur specific types of blood clots following vaccination with the COVID-19 Vaccine AstraZeneca, the Medicines and Healthcare products Regulatory Agency ( MHRA) said today. This includes information on the use of the vaccine in those under 40. The Joint Committee on Vaccination and Immunisation (JCVI) have also published a statement following reports of an extremely rare adverse event after vaccination with the first dose of the AstraZeneca COVID-19 vaccine. Everyone should continue to get their vaccination when asked to do so unless specifically advised otherwise.

Vaccines are the best way to protect people from COVID-19 and have already saved thousands of lives.

The MHRA is now issuing updated guidance for healthcare professionals on how to minimise risks, as well as further advice on symptoms for vaccine recipients to look out for 4 or more days after vaccination.

The data suggest there is a slightly higher incidence reported in the younger adult age groups and the MHRA advises that this evolving evidence should be taken into account when considering the use of the vaccine.

Anyone who did not have these side effects should come forward for their second dose when invited.

By 31 March 20.2 million doses of the COVID-19 Vaccine AstraZeneca had been given in the UK meaning the overall risk of these blood clots is approximately 4 people in a million who receive the vaccine.

The MHRA’s scientific review of UK reports of extremely rare and unlikely to occur specific blood clots with lowered platelets has concluded that the evidence of a link with COVID-19 Vaccine AstraZeneca is stronger but more work is still needed.

The MHRA is not recommending age restrictions in COVID-19 Vaccine AstraZeneca vaccine use.

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